No Way Am I Doing That Experiment

There has been some interesting discussion over at Blue Lab Coats concerning how to respond to peer reviewer comments on a manuscript submitted to a journal. If a journal editor concludes that a submitted manuscript is potentially suitable for publication, then she will send an e-mail to the corresponding author saying something like this:

Based on the reviews, we will be happy to consider a revised version of your manuscript, in which you should modify the manuscript to address the concerns raised by the reviewers. It is important that you address the reviewers’ concerns in your revised manuscript and also in a point-by-point reply to the reviews that indicates how you have responded to each of the reviewers’ comments.

Suppose that the reviewers have asked for additional experiments that there is no fucking way you are going to perform before resubmission. What are the circumstances under which you can finesse this, and still get your paper accepted?