BikeMonkey Guest Post
PalMD, Isis the Scientist and Dr. Charles have been talking a little bit about restarting fitness and dieting regimens, a topic in which I have a small interest. The cover of the August 17, 2009 issue of TIME magazine insists that “Of course it’s good for you, but it won’t make you lose weight. Why it’s what you eat that really counts.” Turning to the feature article on Health penned by John Cloud, all I can note is that the stupid not only burns, but it incinerates all logic and sense for a five block radius. I had trouble getting past the second paragraph:

As I write this, tomorrow is Tuesday, which is a cardio day. I’ll spend five minutes warming up on the VersaClimber, a towering machine that requires you to move your arms and legs simultaneously. Then I’ll do 30 minutes on a stair mill. On Wednesday a personal trainer will work me like a farm animal for an hour, sometimes to the point that I am dizzy — an abuse for which I pay as much as I spend on groceries in a week. Thursday is “body wedge” class, which involves another exercise contraption, this one a large foam wedge from which I will push myself up in various hateful ways for an hour. Friday will bring a 5.5-mile run, the extra half-mile my grueling expiation of any gastronomical indulgences during the week.

30 minutes? Maybe “an hour”? Four workouts per week for which the only one potentially useful for acute weight regulation purposes is the single 5.5 mile run? And from this the article claims that “exercise” is not useful for weight management?

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HAHAHAHAHAHHAHHA! Okay dope fans….go beat up on the new doc in town for awhile….

CB1 receptors affect the function of the presynaptic terminal. When CB1 receptors are activated, they signal through G proteins to close calcium channels, preventing entry of calcium into the terminal. Calcium is needed for vesicles to fuse with the membrane and release inhibitory neurotransmitters into the synapse. So CB1 signaling stops inhibitory neurotransmitters from being released to the postsynaptic neuron. CB1 receptor activation also results in opening of potassium channels. In a resting neuron, these channels are closed. Outflow of positively charged potassium ions leads to increases in the net negative charge across the membrane. This is called hyperpolarization, the opposite of depolarization. As you might imagine, since depolarization causes neurons to fire, hyperpolarization keeps a neuron from firing. This further decreases the chances that neurotransmitter will be released from the presynaptic terminal. There are some other effects too, which I won’t detail here.

Now let us see, do you think this closing bit is a tad optimistic?

I hope that this helps to make the effects of marijuana make more sense. For the record, I am not interested in discussing policy or the legal status of the drug. I am just here writing about how it works.

PhysioProf linked to this post from The Witty Mulatto who normally blogs at The Madness is the Method. I would call this the money quote but the whole thing is full of ’em:

White organizations everywhere create entire commissions and councils surrounding diversity. Their mission statements usually say things like, “We believe the University environment is greatly enriched by the presence of people with diverse backgrounds and cultural perspectives.” They have a lot of pretty words. But what they really mean is, “How can we reach out to people of color and make them want to join our organization?”
The question that logically comes next but is rarely asked is, “Why would people of color WANT to join our organization?”
If you asked THAT question, things would get interesting.

The good Comrade, denizen of White Institutions, has this to say:

As a member of a white organization, I can say from personal experience that this is, indeed, exactly what “diversity” ends up meaning for us, and how we strategize about it.
I have participated in many discussions concerning “How can we reach out to people of color and make them want to join our organization?” as well as “What can we do to improve the prospects of people of color succeeding within our organization?” I have never had a single discussion concerning “Why would people of color WANT to join our organization?”

Well, I’m a member of multiple white organizations and he’s high as a kite.

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