RIP: Joe Brady

August 5, 2011

A towering legendary figure of behavioral pharmacology and the drug abuse sciences has passed on.

Joseph V. Brady, Ph.D. [Department, PubMed, Neurotree] died Friday July 29, 2011 at the age of 89. He earned his doctorate in 1951 from the University of Chicago, worked at Walter Reed Institute from 1951 to 1970 and spent the balance of his career at Johns Hopkins University.
His most recent paper listed in PubMed was on the effects of gamma-radiation,

Hienz RD, Brady JV, Gooden VL, Vazquez ME, Weed MR. Neurobehavioral effects of head-only gamma-radiation exposure in rats.Radiat Res. 2008 Sep;170(3):292-8.

is a continuation of his longstanding association with NASA and spaceflight. Oh yes, Joe Brady trained the first space chimps.

Dr. Brady’s earliest publications focused on the creation of an animal model of anxiety using a shock conditioning procedure. As you wander across the PubMed listings for articles authored by Joe Brady, you will find early studies using intracranial self-stimulation reward, HPA axis and cardiovascular responses to stress and, of course, studies of drugs of abuse.
As noted in a post noting the passing of Bob Schuster earlier this year, Dr. Brady was also instrumental in the founding of a major model of drug seeking in animals, the intravenous self-administration procedure.

Clark, Schuster and Brady (1961) implanted two rhesus monkeys with internal jugular vein catheters and demonstrated that the monkeys would press a telegraph key for saline infusions. Furthermore, the provision of drinking water to the animals decreased the amount the monkeys would press the key, suggesting that this behavior was sensitive to “drive” (this term for motivation was popular then). The authors quite naturally speculated that this model would be useful for “experimental analysis of the reinforcing properties of many pharmacologic agents”.

Dr. Brady continued to develop and work with self-administration models in animals as well as to establish human laboratory procedures for evaluating psychoactive drugs. In these efforts, he and his colleagues at Hopkins generated much of the knowledge that we have about the abuse liability of many drugs, both recreational and therapeutic.
Dr. Brady was also instrumental in bringing methadone therapy to heroin addicts in Baltimore, including the innovative use of mobile facilities.
For those who are interested, there is a nice review of Dr. Brady’s contributions by J. E. Barrett.
The available public record does a much less effective job at communicating the degree to which Joe Brady influenced science and the generation of knowledge through training and mentoring other scientists. The Neurotree entry is woefully deficient. Many of those whom we count as the luminaries of drug abuse science routinely mention some bit of wisdom or training experiences they gained through association with Dr. Brady….often couched as “Joe’s Rules” or “Brady’s Rules”. The one I have referred to most frequently on this blog is, I believe, one to the effect of:
Never turn down a job you haven’t been offered yet“.

One Response to “RIP: Joe Brady”

  1. haber Says:

    adamsın admin saol..


Leave a Reply

Fill in your details below or click an icon to log in: Logo

You are commenting using your account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s

%d bloggers like this: