Outcome of SABV initiative
June 8, 2016
I was just thinking the coming 9 mo should reveal a steady trickle of one to two Figure stabs at sex-differences comparisons.
I’m predicting that some of the people who generated their first studies as Preliminary Data to head off SABV grant critique are going to publish.
Yes, even if results were negative. They’ll need this for the next round to excuse the failure to include the female animals in the next proposals.
DrugMonkey 
June 8, 2016 at 9:27 am
Or male animals… Up till now, I’ve always used females. Many of my colleagues who work with large animals find females easier than males. Believe me, I will publish showing that in the systems in which I work, inter-individual variation swamps inter-sex variation to the point where the latter is not significant.
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June 8, 2016 at 11:50 am
We use everything we can get regardless of sex. In complicated genetic crosses where we only get 1/16 animals with two floxed alleles, a Cre transgene, and a reporter, we aren’t going to be picky about whether it happens to be a male or female.
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June 8, 2016 at 11:57 am
I’m switching to Hermissenda, a hermaphrodite. A bit sluggish for operant tasks, but at least no SABV bullshit to deal with.
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June 9, 2016 at 8:39 am
Draino and I have the same issue. The low frequency of our multigenic mice coupled with our budget will not allow us to wholeheartedly fulfill the SABV mandate.
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June 9, 2016 at 11:58 am
Watch for upcoming articles by Sabra Klein of Johns Hopkins. Vaccines act differently in males and females.
This one is published:
Estrogenic compounds reduce influenza A virus replication in primary human nasal epithelial cells derived from female, but not male, donors. Am J Physiol Lung Cell Mol Physiol. 2016 Mar 1;310(5):L415-25. doi: 10.1152/ajplung.00398.2015. Epub 2015 Dec 18.
PMID: 26684252
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June 9, 2016 at 12:06 pm
If the results are negative (i.e. no sex differences), they should reduce their n’s and just go half and half in all experimental groups from then on. That is the point of the initiative, that you just use both.
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June 10, 2016 at 12:20 am
There is no freakin way this is going to happen with rat studies. Genetic models you have to breed, yeah. But off the shelf? No wai. No how.
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June 10, 2016 at 11:53 am
No way what is going to happen with rat studies?
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June 10, 2016 at 5:00 pm
Groups of half M/F
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