The NIH is funded by Congressional appropriation so you should be aware in a very general sense that much of what we NIH-funded investigators do is a mandate of Congress. I also mention now and again that there are Congressional (I guess properly “Legislative”) mandates that seem to delve a little more deeply into specifics than most scientists expect.
The NIH Guide has recently published a reminder Notice for some of these Legislative Mandates that have been around since forever*.

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