An absolutely brilliantly expressed observation on a recent post reminded me of a point that I cannot make frequently enough, whilst we are rambling on about publishing as highly as possible, impact factors and the like. We were discussing the implications of always submitting your manuscripts to journals in which you have high confidence of successful acceptance versus frequent submission to journals of higher repute but less likely acceptance. Coturnix dragged the discussion back around to reality in a comment:

Remember that CNS Disease afflicts a relatively small (but loud and prominent) subset of scientists – those working in biomedical fields, molecular biology, immunology, cancer, etc. and want to get tenure-track jobs at hyper-competitive Ivy League schools.
Most scientists do not do that, do not even consider submitting to CNS, have no wish to ever work at Harvard, laugh at the super-competitive crowd, publish in society journals and have their students nicely employed in nice departments in nice schools around the world.

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