August 18, 2011
I have just been informed that ScienceBlogs will no longer be hosting anonymous or pseudonymous bloggers. In case you are interested, despite extensive communication from many of us as to why we blog under pseudonyms, I have not been given any rationale or reason for this move. Particularly, no rationale or reason that responds to the many valid points raised by the pseudonymous folks.
This is, as they say, not unexpected. It is pretty clear that when corporate flacks ask you for your opinion in response to their reflexive stance they are not in fact going to be influenced. So I do hope none of my colleagues are surprised by this. Disappointed, as am I, but not surprised.
I am not certain when the drop-dead date will occur but you will no doubt be able to find me blogging elsewhere.
A recent paper from Brents et al. (PubMed) presents the data that we’ve been hearing about for the past several months. I think leigh of the Neurodynamics blog (see posts on THC and cannabimimetic/JWH-018 pharmacology), may have been the first to report seeing these data at a meeting and then I ran across them at CPDD this past June.
As many of you are fully aware by now, the past couple years has witnessed the emergence of broad popular use of “synthetic marijuana” or cannabimimetic products. They have been retailed widely as small (usually 3g) packets of various plant materials sprayed with a growing list of synthetic drugs which all seem to have full agonist properties at the endocannabinoid 1 receptor subtype (CB1). A series created by J. W. Huffman have been commonly reported, thus you will see reference to the compounds themselves, JWH-018, JWH-073, JWH-081, etc.